基于邻香草醛缩2-氨基-4-硝基苯酚的Schiff碱有机锡配合物的合成、晶体结构及生物活性.pdf

第31卷第7期
无机化学学报
Vol 31 No. 7
2015年7月
CHINESE JOURNAL OF INORGANIC CHEMISTRY
1321-1328
基于邻香草醛缩2-氨基4-硝基苯酚的
Schiff i碱有机锡配合物的合成、晶体结构及生物活性
蒋伍玖1伍徐孟2刘超1庾江喜1朱小明1冯泳兰张复兴1邝代治*4
(功能金属有机材料湖南省普通高等学校重点实验室,衡阳师范学院化学与材料科学系,衡阳421008)
(湘南学院化学与生命科学系,郴州423043)
摘要:邻香草醛缩2-氨基4-硝基苯酚(H1)分别与ニ丁基氧化锡、二苄基二氯化锡反应,合成了二丁基锡 Schiff碱配合物(1)和单
苄基Schi碱配合物(2)。配合物经元素分析、"HNMR、"CNMR、IR、UV-Vis表征,并用X-射线单晶衍射测定了分子结构。研究了
配体HL及配合物1、2对癌细胞Hela、MCF7、HepC2、Colo205、NCL-H460的抑制活性,结果表明配合物1对这5种癌细胞的抑
制效果优于现有抗癌苭物卡铂,可作为抗癌药物的候选化合物。在Tris缓冲溶液中,以EB做为荧光探针,用荧光光谱法研究了
配体HL及配合物2与鲱鱼構DNA的相互作用,结果表明配合物与DNA作用主要是由于Scif碱配体协同效应所致。
关键词:有机锡; Schiff碱;晶体结构;生物活性
中图分类号:0614.432
文献标识码:A
文章编号:1001-4861(2015)07-1321-08
DOI:10.11862/CJIC.2015.116
Syntheses, Crystal Structures and Biological Activity of Schiff Base Organotin
Complexes Based on o-vanillin and 2-amino-4-nitrophenol
JIANG Wu-jiu WU Xu-meng IIU Chao YU Jiang-xi ZHU Xia
FENG Yong-lan ZHANG Fu-xing KUANG Dai-zhi* o-ming
(Key Laboratory of Functional Or an metallic Materials of Hengyang Normad University, College of Hunan Province
Depa me t of Chemist y and Mar ad Science, engang Nomad University, Hengyang, Hunan 421008, China)
Department of Chemistry and Life Science, Xiangnan University Chenzhou, Hunan 423043, China)
Abstract: Schiff base organotin complexes 1 and 2 have been synthesized via the reaction of the o-vanillin-2-
amino-4-nitroenol hiff base(H with the dibutyl in xie and the dibenzyltin dichloride, respectively. The
complexes have been characterized by IR, H NMR, C NMR spectra, elemental analysis and the crystall
structures have been determined by X-ray diffraction. The anticancer activity of HL, I and 2 against five species
of cancer cell which are Hela, MCF7, HEPG2, Colo205, NCI-H460 were tested respectively, and the tests showed
that complex I was more active than carboplatin against tested carcinoma cell lines and has a potential
application of drug preparation. The interaction between Schiff base ligand, complex 2 and Herring sperm DNA
were studied by EB fluorescent probe, the result shows that fluorescence quenching was really resulted from the
synergistic effect of the Schiff base ligand. CCDC: 939077, 1; 939078, 2
Key words: organotin; Schiff base; crystall structure; biological activity
收稿日期:2014-12-28。收修改稿日期:2015-01-26。
湖南省科技计划项目(No。2013T2025,2014NK3086,2014FJ3060和自然科学基金(No.133112),溯南省普通高校重点实验室开放基金
项目(No.13K105,14K0l4),湖南省教育厅基金项目(No.14C017),功能金属有机材料湖南省普通高校重点实验室开放基金项目
CNo13KO1,13KO4,CN14KO1)资助。
*通氓联系人。E- mail hnkcq@ gecom;会员登记号:SO6.N8374M1012。