甲壳素酰化改性的研究进展.pdf

化工.进展
CHIEMIICAL INDUSTRY AND ENGINEERING PROGRESS
2016年第35卷第7期
erereveree
综述与专论
甲壳素酰化改性的研究进展
施文涛,陈鹏
(中国科学院宁波材料技术与工程研究所,中国科学院海洋新材料与应用技术重点实验室,浙江省海洋材料与
防护技术重点实验室,宁波市高分子材料重点实验室,浙江宁波315201)
摘要:甲売素作为一种来源广泛的生物质材料,具有良好的生物相容性和抑菌性,可用于药物缓释、伤口包覆、
组织植入、生物分离、重金属吸附等高附加值领域,但强烈的氧键作用使其不熔难溶,需经改性以促进其加
和应用。本文简要回顾了甲売素酰化改性的发展历程,重点介绍均相条件下甲売素的各种酰化方法,如在甲破
酸、氯化锂/ニ甲基乙酰胺、离子液体、三氟乙酸酐中进行反应,以及在非均相条件下提高酰化效率的各种方法,
如优选催化剂、结构活化等,比较了各种方法的优缺点、并简述了甲売素酰化产物的性能特点和应用。日前甲
売素非均相酰化工艺较成熟,已实现エ业化,但仍有一定的局限性和缺点。最后展望了均相和非均相酰化可能
的改进方向
关键词:甲売素;酰化;均相;非均相
中图分类号:O636.1文献标志码:
文章编号:1000-6613(2016)07-2166-07
DOI:10.16085j-is.1000613.2016.07.03
Advances in acylation of chitin
SH1 Wentao, CHEN Peng
(Ningbo Institute of Materials Technology and Engineering, Chinese academy of Sciences, Key Laboratory of Marine
Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo
Key Laboratory of Polymer Materials, Ningbo 315201, Zhejiang, China
Abstract: As one of the major bio-based materials, chitin shows excellent bio-compatibility and
anti-bacterial properties and finds applications in many high value-added areas, such as drug release
wound healing, tissue implantation, bio-separation engineering and heavy metal absorption, etc
However, chitin is featured by extensive hydrogen bonding, making it unable to melt and difficult to be
dissolved. Therefore, modification is important to facilitate the processing and application of chitin. In
this article, the current state of acylation of chitin is reviewed by comparing different acylation methods
under both homogeneous and heterogeneous conditions. Focus is on the homogeneous reactions in
methanesulfonic acid, lithium chloride/dimethylacetamide, ionic liquids and trifluoroacetic anhydride
Methods for improving acylation efficiency under heterogeneous conditions are described, such as
optimizing the catalyst and structural activation. The properties and applications of acylated chitin are
Iso introduced. Although the acylation of chitin under heterogeneous conditions has been well
developed, there are still some limits and shortcomings. This paper highlights the significant
advantages of trifluoroacetic anhydride method under homogeneous conditions, as well as strategies for
improving the heterogeneous acylation of chitin
收稿日期:2015-09-09:修改稿日期:2016-03-04
第一作者:施文涛(1983-,男,工程师,从事甲売素改性及其湿法
基金项目:国家自然科学基金(51273207)及守波市国际科技合作项
纺丝研究。E-mailswtk596@163.com。联系人:陈,研究员,从事高
目(2013D10002)
分子改性与加工工艺研究。E-mailphen(@nimte.cn