氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物合成和生物学应用.pdf

第29卷第9期
尢机化学学报
Vol 29 No 9
2013年9月
CHINESE JOURNAL OF INORGANIC CHEMISTRY
1969-1978
氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物:合成和生物学应用
Mostafa M I! Khalil Eglal R Souaya Eman H Ismail"Eman Rabie
(Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt. (.
Chemistry Department, Faculty of Science, Taibah University, Al-madina Al-munawarah, B.: 344
Kingdom of Saudi Arabia(沙特阿拉伯王国
摘要:以氨三乙酸HNTA2为主要配体,缬氨酸 valine)或亮氨酸( leucine)为次要配体在徴酸性介质中合成了Ni(ID,Cu(D, and Zn
⑩的三元配合物。用元素分析、热分析、 FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的二元配合物。结果表明,二元
配合物可在金属(M:氨三乙酸( EINTA):缬氨酸( valine)或亮氮酸( leucine)=l:1:l时制得,其分子结构为[M( HNTA)( valine)(HO)
1.5H0 and IN(HNTA) eucine(HO)l-1.5H2O(其中M-NiI①)orCu(I)和HZn(NTA) valine(H2O)H10。标题三元过渡金属配合物为
八面体对称构型。同时研究了该三元配合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,黄曲霉菌(菌株从开罗大学理学院微分
析中心获得)的抗菌活性。根据推荐的知名方法用标准的抗菌和抗真菌剂进行体外测试 In vitro)以评估我们的新制备的配合物
对细菌和真菌物种的生长抑制活性。
关鍵词:缬氨酸;亮氨酸;三元配合物;生物学应用
中图分类号:0614.121;0614.8113;0614.241
文献标识码:A
文章编号:1001-4861(2013)09-1969-10
DOL:10.3969/iss1001-4861.2013.00.319
Ternary Transition Metal Complexes of Nitrilotriacetic Acid and aline or Leucine
Synthesis and Biological Applications
Mostafa M H Khalil Eglal R Souaya Eman H Ismail*2 Eman Rabie
Chemistry Department, Faculty of Science, Min Shams University, 11566, Abbassia, Cairo, Eyt.
(Chemistry Department, acudy of Science, aiba Universit, Al-madina Al-munwarah B O: 344,Kin om of Arabi)
Abstract: Ternary complexes of Ni(ld, Cul), and Zn I)with ni acetic acid HNT as a primary ligand and
valine or leucine as a secondary ligand were synthesized in slightly acidic medium. The new complexes were
characterized by elemental analysis, FTIR. Uv-vis spectroscopy. thermal analysis, magnetic measurements and
mass spectroscopy. The results indicate that the ternary complexes are isolated in M HNTA valine(or leucine)
ratio of 1: 1 and the molecular structures are suggested to be [M(HNTA(valine)(H20)2 ]. 1. 5 0 and M(HNTA
leucine)(H 0) 1 5H 0, where M=N( or Cu(and H [ Zn(NTA)(valine (H ) H O. The suggested geometry of
our ternary metal complexes is an octahedral symmetry. The antimicrobial activities of prepared complexes
against Eschech coli, t tococcus aureus, Candida albicans and A e us fus (isolates from
Microanalytical Center, Faculty of Science, Cairo University )were also investigated. The complexes were tested in
vitro to assess growth inhibitory activity against the bacterial and fungal species with standard antibacterial and
antifungal agents according to the recommended known method
Key words: valine; leucine: ternary complexes; biological applications
收稿日期:2013-02-16。收修改稿日期:2013-05-28
*通讯联系人。E-mail:drscience_7@katmai.com