胃溶型丙烯酸树脂乳液的制备.pdf

第41卷第2期
应用化工
2012年2月
Applied Chemical Industry
Feb.2012
胃溶型丙烯酸树脂乳液的制备
刘超
(安徽理工大学化学工程学院,安徽准南232001)
摘要:采用乳液聚合法,以甲基丙烯酸甲酯(MMA)和甲基两烯酸二甲氨基乙酯(DM)为单体,制备了可直接用于
药物包衣的胃溶型丙烯酸树脂乳液。结果表明,当温度为65℃,单体摩尔比为1:1,引发剂和乳化剂用量分别为
0.6%和0.3%,采用单体连续滴加法时,可制得稳定的乳液,聚合物分子量为14.9万。在180℃以下,产品的失重
率基本不随温度而变,而在180℃以上,失重率随温度升高而増加。聚合物膜在缓冲溶液屮的失重率隍p的增加
而减小,当pH为1.0和2.0时,膜几乎全部溶解,pH为3.0时,膜的失重率为65.0%,在pH为4.0时,失重率迅速
降低到32.8%,到pH为7.0时,膜已基本不溶。
关键词:丙烯酸树脂;药物包衣;乳液聚合
中图分类号:TQ31;0630;0631文献标识码:A文章编号:1671-3206(2012)02-0297-03
Preparation of stomachic acrylic resin emulsion
LIU Chao
College of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, China)
Abstract: Acrylic resin emulsion which can be used for drug coating directly was prepared by emulsion
polymerization with methyl methacrylate (MMA and 2-(di-mthylamino )ethyl methacrylate(DM)as
monomers. The results showed that the stable emulsion can be successfully prepared when the temperature
was 65 C, molar ratio of monomers was 1: 1, dosage of initiator and emulsifier was 0.6% and 0.3%, te
spectively, and the monomer was added continuously. Molecular weight of polymer was 1. 49 10
Weightlessness rate of the product almost had no change with temperature change when the temperature
was below 180 C, but increased with increasing temperature when the temperature was above 180 C
Weightlessness rate of the film in the buffer solution decreased with increasing PH, the film almost di-
solved completely when the PH was 1.0 and 2.0, and weightlessness rate was 65.0%o when PH was 3.0
then reduced to 32.8% rapidly when PH was 4.0, and the film was almost insoluble when PH increased
o7.0.
Key words acrylic resin; drug coating; emulsion polymerization
丙烯酸树脂是常用的高分子薄膜包衣材料,该进行了研究
类材料安全无毒,在体内不被酶破坏,不吸收也不参1实验部分
与代谢,成膜性好,因而得到广泛地应用。国外1.1试剂与仪器
的德国罗姆(Rohm)药厂已推出系列产品,如Eud-
甲基丙烯酸甲酯(MMA)、甲基丙烯酸二甲氨基
rait I30D, Eudragit RL30D等2,国内也有相应的乙酯(DM)、过硫酸铵(APS)、十二烷基硫酸钠
品种,但规格不齐全。目前,国内外主要以溶液聚合(SDS)、二甲亚砜(DMSO)等均为化学纯。
生产丙烯酸树脂材料,在包衣过程中必须溶在有机
HH-2型数显恒温水浴锅; VECTOR33型傅里叶
溶剂中オ能进行包衣。它们不但因易燃性、挥发性变换红外光谱仪;SDT2960型热失重及高温差联用
等对操作者的人身安全带来威胁,而且环境污染问仪,S3000型扫描电子显微镜0.53mm乌式貓度
题也是不可估量的。乳液聚合法具有合成方法绿计。
色,解决有机溶剂包衣带来的污染、挥发和价格昂
2实验方法
贵等问题。本文对胃溶型的丙烯酸树脂的乳液聚合
以MMA、DM为单体,通过控制两者的摩尔比,
得到溶解性和分子量合适的聚合物。向三口烧瓶中
收稿日期:2011-12-03修改稿日期:2011-12-13
作者简介:刘超(1987-),男,安徽六安人,安微理工大学在读硕士研究生,师从张晓梅教授,从事药用高分子材料研究。
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