胶原蛋白自组装生物功能材料的研究进展.pdf

化
工.
进展
2017年第36卷第6期
CIIEMIICALINDUSTIRY AND ENGINEERING PROGRESS
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综述与专论
胶原蛋白自组装生物功能材料的研究进展
王瑞瑞2,王鸿儒
(陕西科技大学轻工科学与工程学院,中国轻工业皮革清洁生产重点实验室,陕西西安710021:
2青海师范大学化学化工学院,青海西宁810008)
摘要:胶原蛋白在体外自组装形成高度有序的网状結枸,有利于细胞的黏附、増殖、扩散和迁移,具有良好的生
物相容性、伏异的カ学性能、可生物降解性和弱抗原性。本文首先介绍和分析了胶原蛋白自组装功能材料的4
种组装方法,即模板自組装法、原位自组装法、定向自组装法和诱导自组装法和分析的研究现状;比较了4种
自组装方法的组装原理和组装特点;然后总結了胶原蛋白自组装生物功能材料作为组织替代材籵,靶向给药材
料,光、电、声特异传导功能材料在再生医学、基因治疗、药物设计、组织工槿、医学影像等领域的应用现状
和发展趋势:最后指出了胶原蛋白自组装生物功能材料今后的研究方向,表明胶原蛋白自组装生物功能材料在
生物医学领域具有广阔的应用前景。
关键词:蛋白质;自组装:制备;功能材料:生物医学工程
中图分类号:TQ93文献标志码:A文章编号:1000-6613(2017)06-215-07
D)O』:10.16085/1.1sSn.1000-661.3.2017.06.034
Progress of research on collagen self-assembly biological functional
materials
WANG Ruiri- 2, WANG Tlongr
(Key I. aboralory of I cather Cleaner Production, China National I ight Industry, College of Bioresources Chemical and
Materials Hnginccring, Shaanxi University of Scicnce&Ichnology, Xi'an 710021, Shaanxi, China; College of
Chemistry and Chemical Engineering, Qinghai Normal University, Xining 810008, Qinghai, China)
Abstract: Collagen sclf-asscmblcd into highly ordered nctwork structurc in vitro, which helps to ccll
adhesion, proliferation, spreading, and migration. Collagen self-assembly biological unctional materials
have highly ordered structure characteristics, excellent mechanical properties, good biocompatibility
biodegradability, and low umuogcnic idiosyncrasy. The assembly proccss of thc four sclf-asscmbl
technologies, which are template sell-assembly technology, in situ selr-assembly technology, directed
selfassembly technology and induced self-assembly technology, is described. The status of research on
those four self-assembly technologies is presented. The theory and characteristic of [our self-assembly
technologics is discussed. Thcn, the application of collagen sclf-asscmbly biological function matcrials as
tissuc replaccment material, targeted drug dclivcry matcrial, functional matcrial of spccific conduction of
light, electricity, sound, is summarized. The development trend of collagen self-assembly biological
lunction materials in regenerative medicine, gene therapy, drug design, Lissue engineering, medical
imaging, etc, is identified. Finally, the direction of future development of collagen self-assembly
biological function matcrial is proposcd. Rcsults show that the collagen sclf-asscmbly biological
functional materials have broad applicalion prospects in biomedical field
Kcy words: protein; self-assembly; preparation; functional materials; biomedical engineering
收稿日期:2016-1104:修改稿日期:2016-11-21。
wangruirul206a163.cm。联系人:王鸿儒,博土,教授。F-mail:
第一作者:王瑞瑞(1980一),女,博士研究牛,副教授。上-mail:
anghru(atom. com
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