氨基酸微量元素螯合物-蛋氨酸铜的制备工艺研究.pdf

China Food Additives开数应用
氨基酸微量元素螯合物一蛋氨酸铜的
制备工艺研究
李放1,徐风1,高文亮2,*
(1.重庆市水产技术推广总站,重庆4000,2.重庆大学化学化工学院,重庆40004
摘要:氨基酸微量元素螯合物作为新一代微量元素添加剂,具有良好的化学稳定性、易消化吸收性、生
物学高效价性等优点,是一种安全环保的新型绿色添加剂。本文采用蛋氨酸为前驱体,研究其微量元素鳌合
物一蛋氨酸铜的化学合成。通过正交实验1L(34)设计确定了蛋氨酸铜的最佳合成工艺,分析了多种实验条件
对蛋氨酸铜合成的影响。实验表明,有机铜源具有比无机铜源更高的产品收率,最佳工艺条件是:蛋氨酸和乙
酸铜的摩尔比为3:1,反应温度为80℃,反应时间为2.0h,蛋氨酸的初始浓度为0.40molL。最后,通过红
外光谱、紫外一可见吸收光谱、X射线粉末衍射及热重分析等手段对所合成的螯合物的结构及性质进行分析
该制备工艺简单,产率较高,成本很低,无污染,具有非常好的工艺应用前景。
关键词:蛋氨酸;金属微量元素;螯合反应;营养添加剂
中图分类号:TS202.3/S9%63.7344文献标识码:A文章编号:1006-2513(2018)01-0146-07
Preparation of amino acid based trace elements chelates-copper
methionine
LI Fang XU Feng GAO Wen-liang
(1. Chongqing Fisheries Technical Extension Center, Chongqing, 400020]
2. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044)
Abstract As a new generation of race element additives, amino acid-based trace element chelates have exhibited
some distinct advantages such as good chemical stability, easy digestion and absorption, and high biological
efficiency. Therefore, it is considered as a safe, environmentally-friendly green additive. In this paper, the synthesis
of copper methionine-a chelate of amino acid based trace element was investigated in using methionine as the amino
acid precursor. The optimum operational parameers were obtained by orthogonal experiment L(3) . The influence
on the yield of copper methionine was analyzed. The results indicated that organic copper compound had a higher
yield than inorganic ones, and the optimal reaction conditions were determined as follows: nmethiomime: nu(Ac)2=
3.0, reaction temperature 80, reaction nerval 2.0 h and initial methionine concentration 40/. Finally, R
spectrum, Uv-vis spectrum, XRD and TGA were used to characterize the structure and physiochemical properties. In
summary, this new technique of preparing copper methionine chelate has the advantages on its simplicity, high yield
low cost and non-pollution. It has a potential applicable prospect in nutrition additives in the future
Key words: methionine; metal trace element; chelation reaction; nutritional additive
收稿日期:2017-08-11
通讯作者
基金项目:重庆市科技计划重大项目(CSTC2010A4056
作者简介:李放(1984-),女,硕士,工程师。研究方向:水产品质量控制与检测,营养强化剂。
018年第1期
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