麦饭石含量对载药复合凝胶小球释药性能的影响.pdf

第23卷第10期
化学研究与应用
2011年10月
Chemical Research and Application
Oct.,201
文章编号;1004-1656(2011)10-1341-05
麦饭石含量对载药复合凝胶小球释药性能的影响
杨会霞'2,王文波,张俊平',王爱勤
1.中国科学院兰州化学物理研究所,兰州730000
2.中国科学院研究生院,北京100039)
摘要:以瓜尔胶-g聚丙烯酸/麦饭石复合水凝胶( GG-E-PAA/MS)和海藻酸钠(SA)为原料,双氯芬酸钠(DS)
为模拟药物,采用离子凝胶法制备了载药复合凝胶小球,考察了pH敏感性以及MS含量对复合凝胶小球的包
封率、裁药率、溶胀性和药物释放行为的影响。结果表明:凝胶小球具有明显的pH敏感性,在不同pH介质中
溶胀率和释放速率不同,在模拟胃液中基本不释放药物,而转人模拟肠液2h后其药物累积释放率就超过了
60%;另外,与不含MS的样品相比,随着MS的增加,包封率、载药率、溶胀率和药物累积释放率而减小,表明
在载药凝胶小球中引入MS,可以减缓药物的突释效应。
关键词:麦饭石;凝胶小球;pH敏感性;控制释放;双氯芬酸钠
中图分类号:0636.1文献标识码:A
Effect of medicinal stone content on drug release behavior of
diclofenac sodium-loaded composite hydrogel beads
YANG Hui-xia", WANG Wen-bo_, ZHANG Jun-ping, WANG A
(1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China
2. Graduate University of the Chinese Academy of Sciences, Beijing, 100049, China
Abstract: A novel guar gum-g-poly(acrylic acid)me icial so/um agnategg-g-pa/MS/SA)hydrogel beads were pre
pared y the ionic gelation echnique Efets of MS content on the swelling ropery, encapsulation efficiency and drug release be
haviors were investigated using diclofenac sodium(DS)as a model drug. ph-sensitive properties and in vitro release kinetics of DS
from the hydrogel beads were also studied. The results showed that DS was hardly released from the hydrogel beads in simulated gas
tric fluid, however, the cumulative release ratio was over 60%in simulated intestine fluid after 2h, which indicated that the hydro
beads had good ph-sensitive. In addition, the encapsulation efficiency, swelling ratio and DS cumulative release were slowed down
obviously with increasing MS content of the prepared hydrogel beads, which revealed that incorporating MS into the hydrogel beads
can improve the burst release effect of the drug.
Key words: medical stone; hybrid composite, ph-sensitive; controlled release; diclofenac sodium
近年来,具有三维网络结构的pH敏感聚合物合p敏感水凝胶成为了当前研究的热点。在
水凝胶在医药领域的应用引起人们广泛关注。聚合物水凝胶中引入无机成分,不仅可以改善聚
随着pH敏感水凝胶研究的深入,聚合物/无机复合物水凝胶的网络结构,而且可以有效调控水凝
收稿日期:2010-12-27修回目期:2011-05-09
基金项目:中国科学院“优秀博士学位论文、院长奖获得者科研启动专项资金”资助项目(2008-06)
联系人简介:王爱勤(1963-),男,研究员;主要研究方向:功能高分子材料。 Email: awang@ lip. cas.en