无水硫酸铁催化多组分反应合成酰胺基烷基萘酚.pdf

第24卷第12期
化学研究与应用
Vol 24.No 12
2012年12月
Chemical Research and Application
Dec,,2012
文章编号:1004-1656(2012)12-1805-05
Etficient synthesis of amidoalkyl naphthols by a Fe, (SO)-catalyzed
multicomponents reaction
SONG Zhi-guo llu Lian-li, SUN Xiao-hu, WANG Yang, CUI Yan
Management Center for Experimental, Liaoning Province Silicon Materials Engineering Technology
Research Centre, Bohai University, Jinzhou 121000, China)
Abstract: A new protocol for the synthesis of amidoalkyl naphthols by a one-pot three-component condensation of 2-naphthol, al de
hyes, amides/urea under solvent-free conditions at 80 using catalytic amount of anhydrous femic su ate, had been developed
The effects of if eent svens con ios a e amt of catalyst on te yields were investigate. Compared to the reported
methods, the advantages of this novel pro ocol lie in mild reaction conditions, short reaction time, the high yields, avoidance of organ
ic solvent, use of inexpensive catalyst and simple work-up procedure
Key os amoa a l mulcmonens ra ahus f s l e s hesis sl e-free condition
中图分类号:0625.6文献标识码:A
无水硫酸铁催化多组分反应合成酰胺基烷基萘酚
宋志国“,刘连利,孙啸虎,王洋,崔岩
(渤海大学实验管理中心,辽宁省硅材料工程技术研究中心,辽宁锦州121000)
关键词:无溶剂80℃条件下,无水硫酸铁可有效催化2-萘酚、醛、和胺/尿素三组分“一锅法”合成酰胺基烷基
萘酚。考察了溶剂条件和催化剂用量对产率的影响。与已报道方法相比,该方法具有反应条件温和、反应时
间短、产率高、不使用有机溶剂、催化剂廉价易得和后处理步骤简便等优点。
中图分类号:酰胺基烷基酚;多组分反应;无水硫酸铁;一锅法合成;无溶剂条件
Amidoalkyl naphthols are important synthetic as p-toluene sulfonic acid), HNS0,H), Al
building blocks and are used as precursors for syn- (H PO), 5 ), Y(m) Sr(OTR), 7,1 Brnsted
thesis of aw-aminomethyl-8-naphthols which exhibit acidic ionic liquid, Ks C, O3H,O., Indion
cardiac activitv [2] The preparation of amidoalk
Eyl 130, AL,0, -HCIO, 12, montmorillonite K10, and
naphthols can be carried out by a one-pot three-com
sulfuric acid 14. However, some of the reported
ponent condensation of -naphthoi, aldehydes, and methods suffer from disadvantages such as long reac
acetonitrile or amides in the presence of Brgnsted tion time, expensive reagent, toxic and corrosive sol
acids, Lewis acids, and heterogeneous catalysts such vent, high reaction temperature(>100C), high cata
收積日期:2012-03-15;修回日期:2012-08-01
甚金项目:辽宁省硅材将工程中心项目(2009402007)资助
联系人简介:宋志国(1975-),男,实验师,主要研究方向:绿色催化化学。E-mai:Inszgskyt@yahoo.com.cn