草酸降解酶预防治疗草酸钙结石症的研究进展.pdf

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(收稿日期:2014-08-20编辑:陈嘉伟)
草酸降解酶预防治疗草酸钙结石症的研究进展
贺俊斌',林日辉≌,龙寒',梁宇薇,陈阳阳
广西民族大学'海洋与生初技术学院广西高校微生物与植物资源利用重点实验室,2化学化工学院化学与生物转化过程新技
术广西高校重点实验室(南宁53000
泌尿系結石是泌尿系统的常见满和多发满,该病的主要此,探索研究新型的临床药物,预防治疗泌尿系结石症,减
特点是临床治愈后复发率較高,给患者带来了极大的痛苦,轻结石病患者的痛苦,具有重要的科学和现实意义。研究
给家庭带来了沉重的心理和经济上的负担。草酸钙是汝尿表明,泌尿系结石中70%~80%为草酸钙结石2,其形成的
系结石的主要成分,导致草酸钙结石症的重要原因是人体内大致过程是:在高草酸尿感染条件下,在远曲肾小管腔内或
缺乏降解草酸的代谢途径。近年来,研究酶法降解草酸预防肾小管细胞内形成草酸钙结晶,肾组织局部草酸浓度升高使
治疗草酸钙結石症成为该领城的研究热点。本文就酶法降最初形成的结晶继续生长,滞留在肾小管腔内上皮细胞并形
解草酸预防治疗草酸钙结石症的研究进展进行阐述,为探索成结石颗粒,较高的草酸浓度诱发巨噬细胞聚集,吞噬草酸
制备防治草酸钙结石症的药物提供理论基础。<