沙苑子提取液对不同体系中草酸钙晶体生长影响的研究.pdf

第26卷第6期
无机化学学报
Vol26 No6
2010年6月
CHINESE JOURNAL OF INORGANIC CHEMISTRY
1089-1094
沙苑子提取液对不同体系中草酸钙晶体生长影的研究
王萍12沈玉华*1谢安建1
安徽大学化学化工学院,合肥230039
(安徽省中医学院药学院,合肥230031)
摘要:通过与水、氯化钠、正常人尿液体系的比较,重点研究了结石患者尿液体系中加人中药沙苑子提取液对草酸钙晶体生长
的的影响,利用SEM,FTR和XRD等测试手段肘所得品体进行表征。结果发现:在结石患者尿液体系中形成的草酸钙晶体为
水草酸钙(COM晶体,而在这4种体系中加入沙苑子提取液后,只形成二水草酸钙(COD)晶体,表明沙苑子提取液能抑制COM
晶体生长,并且随着沙苑子提取液浓度增大,抑制作用增强。沙苑子抑制草酸钙晶体生长的可能机理进行了探讨。
关键词:草酸钙;泌尿系统结石;沙苑子;抑制
中图分类号:0614.231:R282.7文献标识码:A
文章编号:1001-4861(201006-1089-06
Effect of Extract of Semen Astragali Complanati on Calcium
Oxalate Crystal Growth in Different Systems
WANG Pingl2 SHEN YU-HUAXIE An-jianl
School of Chemistry and Chemical Engineering, A nhui Universitry, Hefei 230039)
(School of Pharmacy, Anhui College of Traditiona Chinese Medicine, Hefei 230031)
Abstract: The growth of Ca crystals in the diluted urine of urinary lithiasis patients with different concentrations
of Semen Astragali Complanalisac)extract was investigated by comparing with the crystallization in difterent
systems such as pure water, sodium chloride aqueous solution and diluted healthy urine. The gained crystals were
characterized by scanning electron microscope(EM), Fourier transform infrared spectroscopy(TR)and X-ray
diffraction (XRD). The results showed that calcium oxalate monohydrate(COM) crystals were the dominant phase
in the diluted pathological urine, while there were only calcium oxalate dihydrate( COD)crystals after the addtion
of extract of SAC in the above four systems. It indicated that SAC could prohibit the growth of calcium oxalate,
and the prevention ability of SAC from the formation of COM crystals increased along with the increase of the
extract concentration. The inhibition mechanism of SAC to the crystal growth of calcium oxalate was also
di
Key words: calcium oxalate; urinary ston Semen Astragali Complanali; inhibition
尿结石是一种危害人类健康的常见病和多发泛研究,但对其作用机理仍然不十分清楚。
病,其中60%~-80%为含草酸钙的结石,近年来人
中草药方剂治疗泌尿系统结石历史悠久,因其
们从不同角度对尿结石的形成及抑制因素进行广疗效显著,且副作用少等优点而备受关注。近年来
收稿日期:2009-09-21。收修改稿目期:2010-03-12。
国家自然科学基金。20671001,20871001),安徽省教育厅重大项目(No2D20070041),高校博士点基企(N20070357002)及安徽省功能
无机材料化学重点实验室基金资助。
通讯联系人
@163.
第一作者:王萍,女,43岁,在职硕士研究生,讲师;研究方向:生物无机化学。