不同载药方式对载三氧化二砷(As2O3)磷酸钙骨水泥(CPC)固化时间和抗压强度的影响.pdf

复?学报(医学版)
Fudan Univ J Med Sci 2014 Jul, 41(4)
483
不同载药方式对载三氧化二砷(As2O3)磷酸钙骨
水泥(CPC)固化时间和抗压强度的影响
张亮王靖2刘昌胜2陈统一1黄晓春26
(复旦大学附属中山医院骨科,康复医学科上海200032;2华东理工大学教育部医用生物材料工程研究中心上海200237)
【摘要】目的探讨不同载药方式对载三氧化二砷( arsenic trioxide,As2O3)磷酸钙骨水泥( calcium phosphate
cement,CPC)固化时间和抗压强度的影响。方法将As2O3粉末与CPC粉末的混合物或载As2O)壳聚糖微球
与CPC粉末的混合物加入固化液制备载药CPC。分别在不同固化液和固液比的条件下,测定载药CPC的固化
时间及抗压强度。结果固化液为4%磷酸氢二钠(Na2HPO,)时,无论CPC直接荷载As2O。或复合载As2O
壳聚糖微球,CPC的固化时间都有明显延长。CPC直接荷载As2O时,药物含量和固液比越大,其固化时间也
越长。将固化液改进为含柠檬酸混合溶液后,复合载药微球的CPC的固化时间延长不明显。直接荷载As2O3
使CPC的抗压强度有所下降,而固化液的改进和壳聚糖微球的复合则能显著提高CPC的抗压强度。结论相
比直接荷载As2O3的CPC,复合载As2O売聚糖微球的CPC具有更好的生物力学性能,并在固化液改进后能
维持适宜的固化时间。
关键词】三氧化二砷(As2O3);磷酸钙骨水泥(CPC);生物力学
中图分类号】R318.01;R318.08文献标志码】Adoi:10.3969/.issn.1672-8467.2014.04.010
Influences of different drug-loading ways on setting time and
compressive strength of calcium phosphate cement(CPC)
loaded with arsenic trioxide(AS2O3
ZHANG Liang, WANG Jing, LIU Chang-sheng2, CHEN Tong-yi, HUANG Xiao-chun
( Department of Orthopaedics, Department of Rehabilitation, Zhon g shan Hos pital, Fudan University
Shanghai 200032, China; Engineering Research Center for Biomedical Materials of Ministry of
Education, East China University of Science and Technology, Shanghai 200237, China)
(Abstract) Objective To explore the influences of different drug-loading ways on the setting time
and compressive strength of calcium phosphate cement(CPC) loaded with arsenic trioxide(As2 O,
Methods The mixture of As, O, and CPC powder, or of chitosan microspheres burdened with As, O
and CPC powder, was blended with setting liquid so as to prepare drug-loaded CPC. Under different
conditions of setting liquids and solid-liquid ratios, the setting time and compressive strength were
measured, respectively. Results When 4% Na, HPO, was used as setting liquid, whether CPC was
compounded with As, O, directly or with chitosan microspheres burdened with As, O,, obvious increase
in the setting time was observed. When CPC was straightly loaded with As2 O,, larger As2 O, dose or
复旦大学上海医学院青年骨干科研启动基金(08L03)
A Corresponding author E-mail: huang. xiaochun(@zs-hospital sh cn