新型防霉剂双乙酸钠的合成研究.pdf

第36卷,第2期
安徽化工
Vol 36, No. 2
2010年4月
ANHUI CHEMICAL INDUSTRY
Apr.2010
新型防霉剂双乙酸钠的合成研究
周本华,张怀红,祁英帆
(盐城工学院化学与生物工程学院,江苏盐城224051)
摘要:双乙酸钠是一种新型防霉剂。在以乙酸和碳酸钠为原料,水作溶剂的条件下合成双乙酸钠。对影响产品质量和收率的主要参数进
行了研究和优化,并确定了最佳工艺条件:n(awom:nso)=4.10:1,反应温度为80-85℃,回流反应时间为2.5-3.0h,溶剂水的质量分
率为10%,结晶冷却速度为2-3℃ /mine。在此最佳工艺条件下,母液全部循环利用,产品收率达到9%%,且质量符合CB12493-90。该方法
具有原料价廉易得,无污染以及易于实现工业化生产等优点。
关键词:双乙酸钠;防霉剂;乙酸;碳酸钠;合成
中图分类号:0623.621文献标识码:A文章编号:1008-553X(2010)02-0017-03
双乙酸钠( Sodium Diacetate,SDA)是一种新型的高用安全的防霉剂,因而在国外其开发和应用一直很受重
效低毒防霉、防腐、保鲜剂,在食品和饲料等领域中广泛视。我国在这方面的工作亦已起步,但供需矛盾突出,产
应用。与常用的防腐剂如苯甲酸类等相比,双乙酸钠量远小于市场需求。
不但生产工艺简单,设备投资少,原料来源广泛,而且具
目前SDA的主要制备方法有乙酸一纯碱法、乙酸
有价格低,效果好,毒性小等优点,是一种新型、高效、使一烧碱法、乙酸-乙酸钠法、乙酸一醋酐一纯碱法以及
收稿日期:2009-12-17
作者简介:周本华(1969-),男,安徽无为人,讲师,东南大学博土研究生,主要从事精细化学品研究与开发及创新药物研究工作,1361574589,
shoubhaaa@sina,comn。
(3 Guo HX, Shi YP. A novel zein-based dry coating tablet design for
Biointerfaces,2009,69(1):109-115
zero-order releaselj ]nt J Pharm, 2009, 370(1-2): 81-86
[7] Wang HJ, Gong SJ, Lin ZX, et al. In vivo biocompatibility and me-
4] Hurtado PL, Murdan S Formulation and characterization of zein
chanical properties of porous zein scaffolds Biomaterial, 2007, 28
microspheres as delivery vehicles J].J Drug Deliv Sci Tec, 2005, 15
27):3952-3964.
(4):267-272.
(8] Wang HJ, Lin ZX, Liu XM, et al. Heparin-loaded zein microsphere
(5] Dong J, Sun Q, Wang JY. Basic study of corn protein, zein, as a bio-
film and hemocompatibility [].J Control Release, 2005, 105(1-2)
material in tissue engineering, surface morphology and biocompati-
120-131
bility]. Biomaterial,2004,25(19):4691-4697.
?国家药典委员会.中华人民共和国药典(第二部)北京:化学
(6 Wang HJ, Fu J X, Wang JY Efiect of water vapor on the surface char
工业出版社,2005:附录66.口
acteristics and cell compatibility of zein films JColloids Surf B
Study of the Degradation Behavior of Zein in Vitro and in Vivo
ZHANG Qun-wei, ZU Li-gen, LU Chuan-hua
School of pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230038
Abstract: Objective: To study the in vitro and in vivo de radation behavior of zein. Methods: 65%(/ml)zein colloid was
prepared with 95% ethanol solution, then colloid was injected into mold to prepare rod zein, through te intrinsic viscosity,
quality changes, and scanning electron microscopy to study of zein in vivo and in vitro degradation process. Results: zein can
be degraded in vivo and in vitro, the surface of zein rods became rough, but length and overall shape of zein rods was not
changed in vi and in vitro e ration, and the degradation rate in vivo was faster than in vitro degradation rate. As the
degradation proceeded, the rod surface became gradually rough, however, the rod surface have emerged with concave-shaped
absorption in the body
Key words: zein; biodegradable material; in vivo degradation; in vitro degradation