大肠癌患者外周血中细胞角蛋白19和癌胚抗原的表达及临床意义.pdf

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(编校:张西敏)
大肠癌患者外周血中细胞角蛋白19和癌胚抗原的表达及临床意义
王前,刘洁,张培军,宋瑞,郭兰栓
Expression of CK19 MRNA and CEA MRNA of the peripheral blood of patients with color-
ectal carcinoma and its clinical significance
Wang Qian, Liu Jie, Zhang Peijun, Song Rui, Guo Lanshuan
Department of The General Surgery, The First Central Hospital of Baoding, Hebei Baoding 071000, China
Objective: Using nested reverse transcription polymerase chain reaction( nested RT-PCR)to detect
the expression of CKI9 MRNA, CE A MRNA in peripheral blood of patients with colorectal cancer technique and study
the clinical significance. Methods: Expression of CK19 MRNA and CEA MRNA was detected by nested RT-PCR in
20 healthy people, 20 patients with colorectal adenoma and 90 cases of patients with colorectal cancer in peripheral
blood. Results: The positive expression rates of CK19 MRNA and CE A MRNA were: 58. 89%(53/90)and 53. 339
(48/90). No CK19 MRNA and CEA MRNA in the control group was found; In 20 cases of colorectal adenoma, ex
pression of CK19 MRNA in 1 cases, the expression rate was 5.00%(1/20 ) no CEA MRNA expression In patients
with colorectal cancer CK19 MRNA, CEA MRNA expression rate was significantly correlated with tumor staging an
tumor metastasis(Ptal cancer has good sensitivity and specificity, can be used to judge the prognosis of patients with colorectal cancer
Key words)colorectal cancer; peripheral blood CK19 MRNA; CEA MRNA; nested RT-PCR
Modern Oncology2015,23(08):1099-1102
【收稿日期】2014
【作者单位】保定市第一中心医院普外科,河北保定071000
作者简介】王前(1981-),男,河北保定人,主治医师,主要从事胃癌、大肠癌及乳腺癌等肿瘤外科研究。E-mail:wangan2000s163.com
通讯作者】郭兰栓(1963-),男,河北保定人,主任医师,主要从事胃癌、大肠癌、肝胆疾病及乳腺癌等普通外科疾病研究。E-mail:s0n-
gruil104@126.com