百令胶囊联合依地酸钠钙治疗成人慢性铅中毒肾损伤的临床效果观察.pdf

12 Chinese General Practice
8)第
?1917
中医·中西医结合研究
百令胶囊联合依地酸钠钙治疗成人慢性铅中毒腎损伤的
临床效果观察
何剑零,谢海英,李青华
【摘要】目的百令胶袁联合依地酸钠钙治疗成人慢性铅中毒肾损伤的临床效果。方法选择2011年6月
013年2月我科治疗的39例成人慢性铅中毒患者,采用随机抽签法分为百令胶联合依地酸钠钙组(联合组,n=
22)和依地酸钠钙组(n=17),检测两组患者治疗前后血铅、尿素氩、血肌酐、血尿酸、尿β2微球蛋白水平,并进
行对比分析。结果两组患者的年龄、性別、铅接触时间、血铅、尿素、血肌酐、血尿酸及尿β2微球蛋白河差异均
无统计学意义(P<0.05);联合组治愈率为82%(18/22),依地酸钠钙组治愈率为70.6%(12/17),差异无统计学
意义(x2=0.88,P=0.35)。组间比较,治疗后两组血铅、屎素氩水平间姜异有统计学意义(P<0.05),两组血尿酸
和屎β2微球蛋白水平间羞异无统计学意义(P>0.05)。组内比较,治疗后依地酸钠钙组尿素、血肌酐及尿β2微球
蛋白水平与治疗前比较,差异无统计学意义(P>0.05),血铅较治疗前降低(P>0.05),血尿酸较治疗前升高(P<
0.05);联合组血铅、尿素魚、血肌酐及尿β2微球蛋白水平較治前下降(P<0.05),血尿酸与治疗前比较,差异无
统计学意义(P>0.05)。结论对合并轻度肾损害的慢性铅中毒患者行依地酸钠钙针驱铅治疗安全有效,联合百令胶
囊治疔可减轻慢性铻中毒肾损伤
【关键词)铅中毒;肾功能不全;依地酸;百令胶衆;治疗结果
【中图分类号】R598,11【文献标识码】Adoi:10.3969/j.jisn.1007-9572.2014.16.029
何剑零,谢海英,李青华、百令胶實联合依地酸钠钙治疔成人慢性铅中毒肾损伤的临床效果观察[].中国全科
医学,2014,17(16):1917-1919
www.chinagp.net
Clinical Effect of Corbrin Capsules Combined with Cana2 -EDTA on Adult Renal Injury Induced by Chronic Lead Poi
soning HE Jian -ling, XIE Hai-ying, L Qing-hua. Depamen of Nephropathy, Shaoxing Peoples Hospital, haoxing
Hospital of Zhejiang University, Shaoxing 312000, China
(Abstract) Objective To investigate the clinical effect of Corbin capsules combined with Cana -EDTA on adult re
nal injury induced by chronic lead poisoning. Methods A total of 39 chronic lead poisonin patients treated in this hospital from
June 2011 to February 2013 were divided randomly into oups A(treated with corbrin capsules combined with CANA2EDTA
n =22), B (treated with Cana -EDTA, n =17) Ievels of blood lead, bloodurea nitrogen(BUN), serum creatinine
(Cr), blood uric acid(BUA), B microglobulin (B -MG) were determined and analyzed comparatively in 2 groups before
and after treatment. Results There was no significant difference in age, gender, duration of lead exposure, blood lead, BUN
Cr, BUA, B, -MG between 2 groups(P <0.05).The cure rate was 82%(18/22) in group A, 70. 6%(12/17)in group
B, the difference was not significant( =0.88, P=0. 35). There was difference in blood lead, BUN between 2 groups after
treatment (P <0.05), there was not in BUA, B -MG (P>0. 05). No difference was noted in BUN, Cr, B2 -MG in group
B after treatment (P> 0.05), blood lead was lower, BUA was higher after treatment than before(P<0.05); Blood lead
BUN, Cr, B, -MG were lower after treatment than before in group A (P <0.05), and there was no difference in BUA between
pre-and post -treatments (P> 0.05). Conclusion CANA -EDTA is safe and effective for adult chronic lead poisoning with
mild renal injury, Corbrin capsules combined with CANA2 -EDTA can alleviate renal injury induced by chronic lead poisoning
Key words] Lead poisoning; Renal insufficiency; Edetic acid; Corbrin capsule; Treatment outcome
铅中毒是世界范围内,特别是发展中国家存在的较为严重
作者单位:312000渐江省绍兴市人民医院(浙江大学绍兴医院
的公共卫生问题,当血液和组织中的铅含量达到一定水平时,
肾内科
可造成血液系统、神经系统、生殖系统、免疫系统、肝脏、肾
通信作者:何剑零,312000断江省绍兴市人民医院(浙江大学绍脏及心血管系统等多脏器损害21。 Lancerceauxin于1862年
兴医院)肾内科;E-mail:hejl04@163.com
报道了第1例铅中蘇肾病患者,但直到19世纪晚期才明确铅
所致的高血压和肾衰竭。即使较低水平的铅接触也可能会加速