双黄升白颗粒在慢性丙型病毒性肝炎抗病毒治疗中升白细胞作用的临床研究.pdf

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Kamary 2015, Vok18 No 3
中医·中西医结合研究
双黄升白颗粒在慢性丙型病毒性肝炎抗病毒治疗中
升白细胞作用的临床研究
吴秋霞,徐振晔,孙庆生
摘要】目的探讨双黄升白颗粒预防性治疗慢性丙型病毒性肝炎干扰亲抗病毒治疔所致白细胞计数减少的临
床疔效。方法选取2011年6月-2013年6月河南省中医院收治的慢性丙型病毒性肝炎惠者62例,采用随机数字表
法分为治疗组32例,对照组30例,分别于千扰素治疗开始同时服用双黄升白颗粒(15g/次,3次/d)和利血生(20
mg/次,3次/d),然后检测每组患者治疗前,治疗后2、4、8周外周血白细胞计数、中性粒细胞计数及骨髋抑制情况。
结果两组治疗前后白细胞计数和中性粒细胞计数比较,差异均有统计学意义(P<0.05);治疗方法与治疗时间存在
交互作用(P<0.05);組间比较,差异有统计学意义(P<0.05);时间间比较,差异有统计学意义(P<0.05)。对
照組22例(73.3%)患者发生骨髓抑制,其中轻度14例、中度6例、重度2例;治疗组12例(37.5%)患者发生骨
抑制,其中轻度9例、中度2例、重度1例。对照组骨髓抑制发生率高于治疗銀(x2=10.980,P=0.011)。结论
双黄升白颗粒预防性用药对于治泞千扰素所致白细胞计数减少较利血生效果好,同时所致骨葹抑制发生率更低,双黄
升白颗粒是一种安全有效的预防千扰素所致白细胞计数减少的有效药物。
【关键词)双黄升白颗粒;肝炎,两型,慢性;抗病毒药;白细胞计数
【中图分类号】R512.63【文献标识码】Bdoi:10.3969/j.iss1007-9572.2015.03.01
吴秋霞,徐振晔,孙庆生,双黄升白颗粒在慢性丙型病毒性肝炎抗病毒治疗中升白细胞作用的临床研究「J].中
国全科医学,2015,18(3):322-325.[www.chinagp.net]
Wu QX, Xu ZY, Sun QS. Clinical observation of shuanghuang shengbai granule in increasing leukocyte effect in antiviral
therapy of chronic hepatitis C [J]. Chinese General Practice, 2015, 18(3): 322-325
Clinical Observation of Shuanghuang Shengbai Granule in Increasing Leukocyte Effect in Antiviral Therapy of Chronic
Hepatitis C WU Qi-xia, U Zhenye, SUN ing-sheng Henan radit onal Chinese Medicine Hospital, Zhengzhou
450002. China
(Abstract] Objective To observe the effect of Shuanghuang Shengbai granule in preventive treatment for interferon
induced leucopenia in patients with chronic hepatitis C Methods
patients with chronic hepatitis C treated in Henan
Traditional Chinese Medicine Hospital from June 2011 to June 2013 were randomly diided into reatment group(31 cases )and
control group (30 cases) . The two groups were given Shuanghuang Shengbai granule(15 g a time, three times per day) and
Ieueogen (20 mg a time, three times per day ) .The periperal white blood cells count, neutrophil count and bone marrow
suppression were detected before treatment, two weeks, four weeks and eight weeks after treatment. Results The white blood
cells count and neutrophil count before and after treatment between the two groups both showed statistically significant differences
P<0.05) .There was interaction between treatment and time(P<0.05 .The inter-group difference was statistically
significant (P<0.05), and the time showed statistically significant difference(P<0.05).22 cases(73.3%)in the control
group had bone marrow suppression, with 14 slight level cases, 6 moderate level cases and 2 severe level cases; 12 cases
(37. 5%)in the treatment group had bone marrow suppression, with 9 slight level cases, 2 moderate level cases and one severe
level case. The control group had higher incidence of bone marrow suppression than the treatment group(x=10.980, P
0.011 ) Conclusion Shuanghuang Shengbai granule has good effect with leucogen in preventing leukopenia induced by IFN
and it is a safe, cheap and convenient drug to treat leucopenia induced by IFN
Key words Shuanghuang shengbai granule; Hepatitis C, chronic; Antiviral agents; Leukocyte count
作者单位:450002河南省郑州市,河南省中医院(吴秋霞);上海中医药大学附属龙华医院(徐振晔);郑州市中医院(孙庆生
通信作者:吴秋霞,450002河南省郑州市,河南省中医院;E-mail:wax0507@163.com