老年高血压患者合并抑郁状态与性别的相关性研究.pdf

(GP Chinese General Practice
专题研讨
老年高血压患者合并抑郁状态与性别的相关性研究
任延平,黄若文,高路,李怀琳
摘要】目的探讨老年高血压患者合并抑都状态与血5-羟色胺(5-HT)和白介素-6(L-6)水平及性
别的相关性。方法老年高血压患者260例,男134例,女126例。患者通过汉密顿抑都量表(HAMD)、老年抑量
表(GDS)和Zung抑郴自评量表(SDS)筛查抑状态,用荧光光度法测定5-HT水平, ELISA法测定L-6水平。
结果43.46%(113/260)的老年高血压患者合并抑都,男性抑发病率为35.07%(47/134),女性为52.38%(66/
126),合并抑都的老年高血压患者血浆5-HT水平明显高于未合并押都患者「(53.6±12.8)pg/I.和(24.610.8
g/L,P=0.004)],L-6水平也明显升高[(38.12±12.74)ngL和(22.45±10.12)ng/L,P=0.007]。结论老
年高血压患者合并护郴状态存在性别差异,女性高于男性,且合并抑都的高血压患者血浆中5-HT、L-6水平升高。
关键词』高血压;抑郝症;性别特性;5-羟色胺;白介素-6
【中图分类号】R749.42【文献标识码】A【文章编号】1007-9572(2010)07-2310-03
Associations between Depression and Gender and 5 -H dr xy tamine/interlewkin-6 in Elderly Patients with Hyperten-
sion RE Yan-ping, AG Ruowen, A L, et ad Dearment ofgeatcadsculr, the First A lied H
tal of Medical College of Xi'an Jiaotong University, Xi'an 710061, China
Abstract) Objective To explore the association between depression and gender and the association between depres
sion and the levels of 5-hydroxyptamine (5-ht)and interleukin-6(il-6) in elderly patients with hypertension. Methods
A total of 60 patients with pension(34 males and females were elle n h su. Te depression status was
valuated with Hamilton Depression rating scale (HAMD), Gerontism Depression Scale (GDS), and Zung Self-rating Depre-
sion Scale (SDS The plasma levels of 5-HT and IL 6 were determined by fluorescence photometry and enzyme linked immu
nosorbent assay(ELISA) .Results The overall incidence of depression was 43.46(113/260)(mae: 35. 07; female
52. 38%).The plasma levels of 5-HT [ ( 53. 6*12.8)w/L. and IL-6 [(38. 12+12. 74)ng/L] in patients with depres
sion were significantly higher than those in patients without depression(24.6+10.8) u/L, P=0.004: (22.45+10.12)
ng/L, P=0. 007; respectively) .Conclusion Women are relatively easier to get depression among patients with hyperten
sion. The plasma levels of 5-HT and IL -6 in plasma may increase in patients with hypertension accompanied with depression
Key words) Hypertension Depressive disorder; Gender identity; 5-hydroxyptamine; Interleukin-6
大量研究显示在老年高血压的发病人群中,抑郁状态的患
基金项目:狭西省攻关项目(2004K14-Cl
病率较高'。躯体疾病伴发精神状态的识别、诊断与治疗严
作者单位:710061陕西省西安市,西安交通大学医学院第一附属重影响老年高血压治疗的达标率,而对老年高血压患者的抗抑
医院老年心内科(任延平,黄若文);西安交通大学校医院(高路);郁治疗有利于血压的控制2。本研究旨在评价老年高血压患
酉安财经学院统计分院(李怀琳)
者性别及血浆5-羟色胺(5-HT)和白介素6(L-6)水平
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(收稿日期:2010-05-05;修回日期:2010-06-15)
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