用基于苯并噻二唑衍生物的比率荧光化学传感器检测氟离子.pdf

第25卷第5期
化学研究
中国科技核心期刊
2014年9月
CHEMICAL RESEARCH
http://hxya.chinajournal.net.cn
用基于恭并噻二唑衍生物的比率荧光化学传感器检測氟离子
艳华“,付成
(江汉大学交叉学科研究院,湖北武汉430056)
摘要:研制了一种用于灵敏、快速地检测溶液中的氟离子的基于萃并噻二唑衍生物的荧光传感器,4,7-二溴
2,1,3-苯并噻二唑与三甲基硅基乙炔通过 Sonogashira偶联反应得到二取代的三甲基硅基乙炔苯并噻二唑;将
该化合物用于检测氟离子,分析了检测灵敏度和选择性.结果表明,在乙腈和水(V/=9:1)混合溶液中,合成
的苯并噻二唑衍生物的最大发射波长峰值为455nm(激发波长为376nm);就所测试的F”,CI,Br~,I
CIO~,AcO~,NO3-,H2PO3,CN和HSO。-等阴离子而言,仅F~可以脱除三甲基硅保护基使得该化合物
荧光最大发射波长蓝移至435nm,荧光强度降低60%,且最低检测限可达4.5×108mol/L.因此,二取代的三
甲基硅基乙炔苯并嚷二唑应用于氟离子检测具有很好的灵敏度和选择性.
关键词:苯并噻二唑;荧光化学传感器;氟离子;检测
中图分类号:O657.39
文献标志码:A
文章编号:1008-1011(2014)05-0482一06
DOI:10.14002/j.hxya.2014,05.010
Detection of fluoride ion by ratiometric fluorescent
chemodosimeter based on benzotiadiazole derivative
YU Yanhua *.FU Che
(Institute for Interdisciplinary Research, Jianghan University, Wuhan 430056, Hubei, China)
Abstract: A ratiometric fluorescent chemodosimeter based on benzotiadiazole derivative has
been developed for detecting fluoride ion (F")in solution sensitively and rapidly. Namely, bis
trimethylsilylalkyne benzothiadiazole was prepared by Sonogashira coupling reaction of 4, 7-di
bromo-2, I, 3-benzothiadiazole and trimethylsilyl ethyne. As-synthesized product was used to
detect F", and the detection sensitivity and selectivity were analyzed. Results show that the e
mission band of the as-synthesized benzothiadiazole derivative in the mixture of acetonitrile and
water(V/V=9: 1)is centered around 455 nm(the excitation wavelength is 376 nm) Among
tested anions such as F", Cl, Br", I, Clo, ", Aco", NO; ,H2 PO2, CN and
HSO4 only F"is able to eliminate the trimethylsilyl(TMS) protective group thereby lead
ing to a blue shift of the maximum fluorescent emission wavelength from 455 nm to 435 nm as
well as a decrease of the fluorescence intensity by 40%, with the detection limit being
4.5X 10" mol/L. This means that bis-trimethylsilylalkyne benzothiadiazole can be well used to
detect F with good sensitivity and selectivity.
Keywords: benzotiadiazole; fluorescent chemodosimeter; fluoride ion; detection
氟是人体所必需的微量元素之一,在形成骨骼组织、牙齿釉质以及钙磷的代谢等方面都起着无可替代的
收稿日期:2014-06…-03
基金项目:江汉大学博土科研启动基金(2014036)
作者简介:喻艳华(1985-),女,助理研究员,研究方向为有机化学,?通讯联系人,E-mail:hpyh@ Baiyun,com