医用臭氧在疼痛治疗中的应用及相关研究.pdf

广东医学2012年5月第33卷第9期 Guangdong Medical Journal May.2012,Vol.33,No.9
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医用臭氧在疼痛治疗中的应用及相关研究
徐清榜,张小洺,张建强
华中科技大学同济医学院附属协和医院疼痛科(武汉430022)
臭氧在医学中应用已有一百多年历史,在疼痛治疗中由2臭氧在疼痛治疗中的应用及研究
于其操作简单、安全性大、创伤较小、费用相对低得到广泛的
臭氧与生物分子的作用包含2个基本过程:一是“臭氧
应用。目前主要应用于推间盘突出症、骨性关节芙、神经病
启动反应”,二是“脂质氧化反应”。这2个反应迅速消耗全
理性疼痛及软鉏织疼痛等疾病,取得了良好的治疗效果且未
部臭氧,最终产生ROS和脂质过氧化物(LOPs)。大量资料
发现明显的不良反应。本文就臭氧在疼痛治疗中的应用及
表明,氧化一抗氧化失衡在疾病的病理过程中普遍存在,并
相关研究做一综述。
起重要作用,臭氧通过激活抗氧化酶来清除氧自由基,维持
臭氧的理化性质
和恢复氧化一抗氧化平衡。臭氧在疼痛领域的作用短效机
臭氧又名“活性氧”,由3个氧原子组成,其相对分子质制可能与生物氧化活性分子有关,长期效应