前列腺癌患者3年生存的预测因素分析.pdf

第37卷第2期
中山大学学报(医学科学版
Vol37 No2
2016年3月
JOURNAL OF SUN YAT-SEN UNIVERSITY (MEDICAL SCIENCES
Mar.2016
前列腺癌患者3年生存的预测因素分析
陈业辉,赵仕佳,仉智,林华欣,李淼沅,聂品,江文,刘燕肯,李鹏麾
(广州医科大学附属市一医院泌尿外科,广东广州510180)
摘要:【日的】分析前列腺癌病人的多种临床指标与其3年生存的相关性,为前列腺癌病人预后判断提供依据。【方
法】回顾性随访分析341名前列腺癌病人的资料,计算3年总生存率,并应用单因素相关分析及多因素 logistic I回归分析年
龄(ACE)、总前列腺特异性抗原(TPSA)、直肠指检(DRE)、经直肠B超结果(TRUS)、前列腺特异性抗原密度(PSAD)、前列腺
移行区体积密度( PSATZ)、肿T2分期,转移情况、 Gleason评分、是否接受治疗等指标与病人3年生存的相关性,并对独立
相关性因素计算 cutoff值及灵敏度、特异度。【结果】本组前列腺癌病人341例,3年的总生存率为57.4%,疾病特异生存率为
60.7%。在单因素相关分析中, Gleason评分、肿瘤T2分期、转移情况及是否接受治疗等指标与3年生存均有相关性(P<
0.05),多因素 logistic I回归分析结果提示仅有 Gleason评分及接受治疗这两个指标是3年生存的独立相关性因素, Gleason评
分是正相关,接受治疗是负相关,P值分别是0.047、0.010,OR(95%CI)分别是1.018(0.837,1.239)、0.321(0.135,0.759)。
Gleason评分 cutoff值是7.5,灵敏度和特异度分别是35.8%、75.3%。【结论 Gleason评分和接受治疗是前列腺癌病人3年生
存的预测因素。 Gleason评分越高及没有接受治疗者,3年生存的可能性越低。
关键词:前列腺癌;预测因素; Gleason评分;治疗
中图分类号:R73
文献标志码:A文章编号:1672-3554(2016)02-0300-05
Predictive Factors of 3-year Survival in Patients with Prostate Cancer
CHEN Ye-hui, ZHAO Shi-jia, ZHANG Zhi, LIN Hua-xin, LT Miao-yuan, NE Pin, JIANG Wen
LIU Yan-qing, LI Peng-hui
(Depa ment of Urology, Guangzhou First Peoples Hospital, Guan zhou Medical University, Guangzou510180, China
Correspondingto:CHENYe-hui,E-mail:cyhly@163.com
Abstract: [ Objective To investigate the correlation between the clinical variables and the 3-year survival rate of patients with
prostate cancer. [Methods The clinical data of 341 patients with prostate cancer were collected and analyzed. The 3-year survival
rate was calculated. The correlation between 3-year survival rate and age(AGE), total prostate specific antigen(TPA), digital rectal
examination (DRE ) Transrectal ultrasound (TRUS), otal prostate specific anti en(TPSA), prostate specific antigen density
(PSAD), prostate specific antigen density of transition zone(PSATZ), tumor stage(TNM), metastasis, Gleason score, treatments
were analyzed by one-way ANOVA and logistic regression analysis. The cutoff value, sensitivity and specificity of the independent
corelation factors were calculated. Results The 3-year survival rate and disease-specific survival rate of 341 prostate cancer patients
were 57.4% and 60.7%, respectively. Tumor staging, metastasis, Gleason score and treatments were correlated to 3-year survival(P
<0.05), whereas Gleason score and treatment were independent correlation factors of 3-year survival by logistic regression analy
he cutoff value of Gleason Score was 7.5. The sensitivity and specificity of Gleason Score were 35.8% and 75.3%, respectively
Conclusion Gleason score and treatment arepredictive factors of ear survival in patients with prostate cancer. Higher Gleason
score or no treatments cause less 3-year surviva
Key words: prostate cancer; predictive factor; Gleason score; treatment
IJ SUN Yat-sen Univ(Med Sci),2016, 37(2): 300-304
收稿日期:2015-11-2
基金项目:广东省自然科学某金(2015A030313731);国家自然科学基金(81273205)
作者简介:陈业辉,通信作者,主任医师,教授,博士,硕上研究生导师,E-mail:cyhly(@163.com