肿瘤嗜神经侵袭和肿瘤微环境研究进展.pdf

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肿瘤嗜神经侵裟和肿瘤嶶环境硏究进展
吴永发,朱超,王建军,王雪琦
Advances in the research of tumor perineural invasion and fumor microenvironment
WU Yong-fa, ZHU Chao, WANG Jian-jun, WANG Xue-qi
Second Militory Medical University, Shanghai 200433, China
Abstract] Perineural invasion(PNI) can cause patients pain and tumors recurrent, so it get more and more focus
Tumor microenvironment is significantly correlate with PNI. Many factors of microenvironment participate the progress
of PNI and PNI can also change the microenvironment. This article is to overview the research between PNI and tumor
microenvironment
Key words perineural invasion; tumor microenvironment; schwann cell differentiation; neurotrophin
Modern Oncology 2009, 17(06): 1170-1173
指示性摘要肿瘤嗜神经侵袭易引起患者炵痛以及肿瘤的复发,越来越受到重视。肿瘤微环境与肿瘤嗜神
经侵袭密切相关,微环境中有多种因子参与了肿瘤嗜神经侵袭,肿瘤嗜神经侵袭也会改变微环境。本文从二
者的相互作用,作一综述。
【关键词】肿瘤嗜神经侵袭;肿瘤微环境;雪旺氏细胞分化;神经营养因子
中图分类号】R73-37
文献标识码】A【文章编号】1672-4992-(2009)06-110-04
肿瘤的嗜神经侵袭( perineural invasion,PNI)是指肿瘤细展的局部浸润转移现象,被认为是恶性肿瘤经典的四种转移
胞在神经纡维周围沿着神经或进入神经朿膜内沿着束膜扩途径之外的第5种转移方式。PNI最常见于腺样囊性癌、黑
色素细胞瘤和胰腺癌,常作为这些疾病独立的预后指标,
【收稿日期
【修回日期
20&-0T1-083
其他肿瘤包括鳞状细胞癌、胆管癌、前列腺癌和直肠癌也存
在PNI。现在临床上认为,PNI不仅会引起患者疼痛,同时也
【作者单位】第二军医大学神经生物学教研室,上海200433
是手术不能彻底切除瘤体和导致术后肿瘤易复发的主要因
【作者简介】吴永发(1985-),男,福建泉州人,在读八年制本科
素
生,主要从事神经损伤与修复的化学生物学研究。
肿瘤微环境( tum