人参糖肽结合耐力运动对高脂血症大鼠血脂和抗氧化功能的影响.pdf

※营养卫生
品学
2014,Wo.35,Mo.17255
人参糖肽结合耐力运动对高脂血症大鼠血脂和
抗氧化功能的影响
刘雪梅,陈文学,杨铭2,丁德伟,杨明2*
(1.长春中医药大学体育教学部,吉林长春13011:2.吉林省中医药科学院,青林长春130012
摘要:目的:观察人参糖肽( ginseng glycopeptide,GP)结合耐力运动对高脂血症大颿降血脂和抗氧化的
作用。方法:采用高脂饲料喂养8周,建立高脂血症大鼠模型。将高脂大鼠按TC含量随机分为高脂模型对照组
(F组),耐力运动组(E组),GGP80mg/(kgd)组(G组),GGP80mg/(kg?d)+耐力运动组(GE
组),将同批未经上述处理的大鼠作为正常对照组(N组),每组10只大鼠,E组与GE组进行8周的中小强
度的跑步训练,期间G组与GE组技80mg/(kg?d)皮下注射给药,正常对照组与模型对照组皮下注射同体积
生理盐水,每天1次,连续8周。实验结東时,检测高脂血症大鼠血清中甘油三酯( triglyceride,TG)、总胆固
醇( otal cholesterol,,TC)、高密度脂蛋白胆固醇( high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白
胆固醇( ow density lipoprotein cholesterin,LDLC)、载胎蛋白A( apolipoprotein A1,ApoA1)、载脂蛋白B
apolipoprotein B,ApoB)、超氧化物歧化酶( superoxide dismutase,soD)、丙二醛( malondialdehyde,MDA)及
谷胱?肽( glutathione,GSHD水平。结果:F组大鼠TG、TC、LDLC、ApoB、MDA水平明显高于N组(P<00l或
P<001),HDL-C、 Apoal、SOD水平明显低于N组(P<0.01或P<0.001)。与F组比较,E組、G组及GE组人
鼠TG、TC、LDL-C、ApoB、MDA水平明显降低(P<0.05或P<0.01或P<0.001),HDL-C、ApoA1、SOD明显升
高(P<05或P<0.001)?与E组比较,G组TC水平明显降低(P<0.05),SOD水平明显升高(P<0.05),对其
他指标无明显差异(Pン0.05);GE组TG、TC、LDL-C、ApoB及MDA水平明显低于E组(P<0.05或P<0.01),
HDLC、SOD和GSH水平明显高于E组(P<0.05)。与G组比较,GE组TG、LDL-C、ApoB及MDA水平明显降低
P<005),SOD、GSH水平明显升高(P<0.05),对其他指标无明显影响(P>0.05)。结论:单纯注射GGP与
单纯耐力运动可降低高脂血症大颛的血脂水平,对机体照质代谢紊乱具有较好的调节作用。GGP结合耐力运动対高
脂血症大鼠的降脂作用优于单纯给予GGP和单纯耐力运动。
关健词:人参糖肽;耐力运动:高脂血症;降血脂;抗氧化
Effect of Ginseng Glycopeptide Combined with Endurance Exercise on Blood Lipids and
Antioxidative Capacity in Hyperlipemia Rats
LIU Xue-mei, CHEN Wen-xue, YANG Ming, YU De-wei,, YANG Ming2
(1. College of Physical Education, Changchun University of Chinese Medicine, Changchun 130117, China
2. Jilin Academy of Traditional Chinese Medicine, Changchun 130012, China)
Abstract: Objective: To investigate the effect of endurance exercise combined with ginseng glycopeptide on blood
lipids and antioxidative capacity in h per ipemia rats. Methods: A rat model of hyperlipidemia was induced by high
fat diet feeding for& weeks. The rats not fed with high-fat diet were selected as the normal control group(group N)
and the hyperlipidemia rats were randomly divided into four groups by total cholesterol, i.e., model control group
(group F), &0 mg/( kg d) GGP group(group G), endurance exercise group (group E), 80 mg/(kgd) GGP coupled with
endurance exercise group(group GE). Group B and group GE were subjected to small and medium-intensity runni
training for weeks. GGP preparation in normal saline was subcutaneously injected to the rats from group G and group
GE at a dose of 80 mg(kg d). The model rats were subjected to subcutaneous injection with normal saline for 8w
At the end of the experiment, total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol (hdl-c
low density lipoprotein cholesterol(LDL C), apolipoproteins Al(APOA1) and B(Apob), superoxide dismutase
收稿日期:2013-11-21
作者简介:刘雪梅(1964-)·女,副教授,学士,研究方向为运动药理学。E-mail:yming9918@sina.com
通信作者:杨明(1964-),男,研究员,学士,研究方向为中药药理学及新药开发。E-mai:ying98@sina.com
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