免疫性血小板减少症ITP.ppt

免疫性血小板减少症ITP 2013-11-29 宋洋 ITP命名演变 idiopathic thrombocytopenic purpura immune thrombocytopenic purpura immune thrombocytopenia:1 Primary ITP 2 SecondaryITP Estimated proportion of different causes of secondary ITP Approach to thrombocytopenia aplasia infiltration ineffective megakaryopoiesis eg. MDS selective impairment of platelet production Causes of splenomegaly infection inflammation congestion maligancy red cell disorders storage diseases immune auto-immune (ITP, SLE drugs infections allo-immune non-immune sepsis DIC, TTP, HUS hypertensive disorders of pregnancy look for splenomegalybone marrow investigation review meds look for underlying disorders review meds THROMBOCYTOPENIA rule out pseudothrombocytopenia SEQUESTRATION PRODUCTION DESTRUCTION Thrombocytopoiesis PLURIPOTENT STEM CELL COMMITTED PROGENITOR CELL RECOGNIZABLE BONE MARROW PRECURSOR CELL MATURE BLOOD CELL myeloblast monoblast pronormoblastred cell neutrophil monocyte basophil platelet CFU-Baso CFU-Eos CFU-GM Classification of ITP disease phases Therapies for the treatment of ITP：when to treat Therapies for the treatment of ITP 谢 谢